Mnss Information and Courses from MediaLab, Inc.
These are the MediaLab courses that cover Mnss and links to relevant pages within the course.
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| When to Suspect Dosage Suspect dosage if varying strengths in reactivity are seen and reactions are in the same phase. Weaker reactions will be seen if suspected antibody is reacting with antigens in the heterozygous state. Stronger reactions are seen if the antigen is present on the testing cells in the homozygous state. This allows more corresponding antibody to bind with the antigen. Remember the antibodies known for showing dosage are: Rh, Kidd, Duffy, MNSs, and Lutheran. Dosage may be seen if cells are R2R2 (DcE/DcE). These red cells have more D antigen sites so reaction with anti-D may be stronger.Refer to Example 5 on the following page. | View Page |
| Antibody investigation Immediate post-transfusion antibody identification results Cell Rh Rhesus Kell Duffy Kidd MNSs P Lewis Lu Results1 Results2 C D E c e Cw K k Kpa Fya Fyb Jka Jkb M N S s P1 Lea Leb Lua Gel IAT Gel IAT 1 rr 0 0 0 + + 0 0 + 0 + 0 + 0 0 + + + +S + 0 0 0 w+ 2 rr 0 0 0 + + 0 0 + 0 0 + + + 0 + + + +S + 0 0 0 0 3 rr 0 0 0 + + 0 0 + 0 + 0 0 + 0 + + 0 + 0 + 0 0 0 4 r"r 0 0 + + + 0 0 + 0 + + 0 + 0 + 0 + + + 0 0 0 0 5 R2R2 0 + + + 0 0 + 0 0 + 0 + + + 0 + 0 + 0 | View Page |
| Antibody identification (2 weeks post-transfusion) Fortunately, the patient's condition stabilized and additional transfusions were not required. Two weeks later, new patient specimens were drawn for antibody studies. Antibody identification results Cell Rh Rhesus Kell Duffy Kidd MNSs P Lewis Lu Results Cell C D E c e Cw K k Kpa Fya Fyb Jka Jkb M N S s P1 Lea Leb Lua Gel IAT* 1 rr 0 0 0 + + 0 0 + 0 + 0 + 0 0 + + + +S + 0 0 1+ 1 2 rr 0 0 0 + + 0 0 + 0 + 0 + + 0 + + + +S + 0 0 w+ 2 3 rr 0 0 0 + + 0 0 + 0 + + 0 + 0 + + 0 + 0 + 0 0 3 4 r"r 0 0 + + + 0 0 + 0 + + 0 + 0 + 0 + + + 0 0 0 4 5 R2R2 0 + + + 0 0 + 0 0 + + + + + 0 + 0 + 0 | | View Page |
| DAT change of status Notice that the patient's DAT is now negative (IAT autocontrol in the panel done 2-weeks post-transfusion is negative). Cell Rh Rhesus Kell Duffy Kidd MNSs P Lewis Lu Results Cell C D E c e Cw K k Kpa Fya Fyb Jka Jkb M N S s P1 Lea Leb Lua Gel IAT* 1 rr 0 0 0 + + 0 0 + 0 + 0 + 0 0 + + + +S + 0 0 1+ 1 2 rr 0 0 0 + + 0 0 + 0 + 0 + + 0 + + + +S + 0 0 w+ 2 3 rr 0 0 0 + + 0 0 + 0 + + 0 + 0 + + 0 + 0 + 0 0 3 4 r"r 0 0 + + + 0 0 + 0 + + 0 + 0 + 0 + + + 0 0 0 4 5 R2R2 0 + + + 0 0 + 0 0 + + + + + 0 + 0 + 0 + 0 w+ 5 6 | View Page |