Mitotic Information and Courses from MediaLab, Inc.
These are the MediaLab courses that cover Mitotic and links to relevant pages within the course.
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| Malignant Cells Malignant cells that have broken away from tumors located in other areas of the body may be seen in spinal fluid. All of the cells in this field are tumor cells. The cells in this slide are characterized by an open, loose chromatin pattern, nucleoli and vacuoles. Notice that the vacuoles are present in both the nucleus and the cytoplasm. Vacuoles in the nucleus are an unusual finding even in tumor cells. Tumor cells are often found in clumps and may have more than one nucleus due to their erratic mitotic patterns. Malignant cells sometimes have an irregular nuclear shape. Bizarre granules may be found in malignant cells but are absent in mesothelial cells.
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| Remnants of erythrocytes nuclei, nuclear fragments, or aggregates of chromosomes which have separated from the mitotic spindle are: | View Page |
| More on Howell-Jolly Bodies Under normal conditions, Howell-Jolly bodies are thought to be remnants of nuclear fragments due to incomplete expulsion of the nucleus. In pathological conditions, they are aggregates of chromosomes which have separated from the mitotic spindle during abnormal mitosis. Single or multiple Howell-Jolly bodies may be found in a red cell. A single HJ body in a red cell may be seen in megaloblastic anemia, hemolytic anemia such as sickle cell anemia and after splenectomy. Megaloblastic anemia or abnormal erythropoiesis is usually present when multiple Howell-Jolly bodies are observed in a single cell. | View Page |
| What is the composition of Howell-Jolly bodies? | View Page |
| What are Cabot rings? Thin, red-violet-staining strands in the shape of rings, figure eights, or shapes of the letter B may on rare occasions be seen in erythrocytes. These structures are called Cabot rings. Although the origin of Cabot rings continues to be illusive, they are not nuclear fragments since they test Feulgen negative. The rings are probably microtubules remaining from a mitotic spindle. Cabot rings have been observed in a few cases of megaloblastic anemia, lead poisoning and other disorders of erythropoiesis, as well as, after a splenectomy. | View Page |
| The RBC inclusions shown in the photograph represent which of the following? | View Page |