Mast cell Information and Courses from MediaLab, Inc.

These are the MediaLab courses that cover Mast cell and links to relevant pages within the course.

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CLIA General Laboratory Review
Which of the following immunoglobulin classes is chiefly responsible for the degranulation of mast cells and basophils:	View Page
Which of the following would not be considered a part of the body's cellular immune system:	View Page

Introduction to Bone Marrow
Please pick the marrow cell from the list below which has highly granular basophilic cytoplasm but does not show nuclear lobation.	View Page
Mast Cells Mast cells are tissue basophils which can occasionally be seen in normal marrow. An increased number of these cells can be seen in a variety of conditions.	View Page
Match the following.	View Page
Match the following.	View Page

Normal Peripheral Blood Cells
Eosinophils in Parasitic Infections and Allergic Reactions Eosinophils are active in parasitic infections and in allergic reactions such as asthma and hay fever, and may be present in great numbers in the peripheral blood during these conditions.Stress, shock, or burns may also cause an increase in this type of cell.Eosinophils modulate an allergic response by liberating substances which can neutralize mast cell and basophil products.	View Page
Mast Cells Mast cells are similar in appearance to basophils, are a separate cell line and are life-long residents of connective tissue throughout the body. They have some functions similar to those of basophils.	View Page

White Cell and Platelet Disorders: Peripheral Blood Clues to Nonneoplastic Conditions
Select the letter representing the cell that may be seen in increased numbers in the peripheral blood smear in immediate hypersensitivity reactions:	View Page
The neutrophil on the peripheral blood smear in this photograph is a mast cell.	View Page
Basophils A basophil and a small lymphocyte are compared in the same field of the upper photograph, A single basophil is shown in the lower photograph.The cytoplasmic granules of the basophil are larger than the granules of toxic granulation.They contain chemical mediators of immediate hypersensitivity, and are found in the cytoplasm and overlying the nucleus (better seen in the lower photograph). Basophilic granules stain metachromatically with toluidine blue indicating the presence of acid mucopolysaccharide or proteoglycans, both thought to be heparin or heparin-like substances.Basophils are related to tissue mast cells, each involved in hypersensitivity responses and following anaphylactic episodes.Under the stimulation of complement components C3a and C5a, many mediators are released from the basophil granules, including histamine, heparin, and eosinophil chemotactic factors of anaphylaxis, or ECF-A.Basophils are the least common neutrophils in the peripheral blood, comprising 2% or less of the differential count.The presence of large granules of irregular size in basophils and the admixture of eosinophilic granules may indicate dysplastic changes associated with myelodysplastic disorders and leukemia.	View Page