Lymphatic Information and Courses from MediaLab, Inc.

Cardiac biomarkers are important in heart disease where there is damage to the myocardium and myocytes. Interrupted or blocked bloodflow and decreased oxygen cause injury to the myocytes and cell death. As the myocytes become necrotic, their membranes are disrupted and intracellular biomolecules diffuse into cardiac microvasculature and then to lymphatics. From there, these compounds, many of which are biomarkers, enter the peripheral circulation.Cardiac biomarkers are relied upon for the detection and monitoring of two categories of cardiovascular disease: Acute Ischemic Disease -- an AMI is the most serious disease in this category Heart Failure

Prenatal treatment of severe HDFN due to anti-D consists of in utero transfusions. Because of significant risks, transfusion is indicated only if fetal monitoring suggests significant hemolytic disease. 1. Intrauterine Transfusion (IUT)IUTs are done when fetal monitoring indicates severe HDFN and the fetus is too premature for early delivery. IUTs involve the intraperitoneal infusion of packed red cells. The success of the procedure depends on absorption of the red cells through the subdiaphragmatic lymphatic vessels of the fetus. 2. Intravenous transfusion (IVT)Because there may be erratic and inconsistent absorption of intrauterine transfusions in severely hydropic fetuses, IVTs were developed. IVTs involve transfusing donor RBC directly into the umbilical vein.