Iron-chelating Information and Courses from MediaLab, Inc.
These are the MediaLab courses that cover Iron-chelating and links to relevant pages within the course.
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| Beta Thalassemia Major Children with beta thalassemia major, also called Cooley's anemia, usually develop clinical signs during their first year of life. They appear to be malnourished and may exhibit abdominal girth expansion. They show skeletal deformations, which are a result of increased erythropoiesis. A common finding is facial bone changes. Other clinical signs include frequent infections, hepatomegaly, splenomegaly, cardiomegaly, gall stones, leg ulcers, and poor growth and sexual development. Death usually occurs by the time these patients are in their early twenties unless treated with blood transfusions along with iron-chelating agents. If no chelating agent is used during treatment life will only be prolonged by about a decade.Beta thalassemia is found most often in populations of people from the Mediterranean, southern China, and India. | View Page |
| Beta Thalassemia Intermedia Clinically, beta thalassemia intermedia is midway in severity between major and minor. Growth and development in children with this disorder can usually be considered normal and most patients have a normal life span. However, they can demonstrate some facial bone deformity and splenomegaly. Transfusions (again with iron-chelating agents) may be used as a supportive therapy. This form of beta thalassemia is most common in eastern Mediterranean countries. | View Page |