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Inflammatory Information and Courses from MediaLab, Inc.

These are the MediaLab courses that cover Inflammatory and links to relevant pages within the course.

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Current Topics in Clinical Microbiology
Middle ear damage in cases of S. pneumoniae infections are caused primarily by:View Page
Gas gangrene may be seen in infections with all the following clostridia except:View Page
Histology of Brain Biopsy

The H & E section of the brain biopsy (left frame)revealed edema of the parencymya with the accumulation of inflammatory cells in the perivascular spaces. The close in view of the exudate (right) frame reveals that the inflammatory exudate is comprised primarily of polymorphonuclear luekocytes. The histologic diagnosis therefore is suppurative meningitis, with culture results necessary to establish the etiologic agent.

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Mycology: Yeasts and Dimorphic Pathogens
Of the following responses, the one observation that would rule out cryptococcosis as the cause of meningoencephalitis is:View Page

Normal Peripheral Blood Cells
Life Span and function of Eosinophils

Eosinophils have a circulating half-life of approximately 18 hours and a tissue life span of at least 6 days.They are capable of locomotion and phagocytosis and can enter inflammatory sites, but do so less readily than neutrophils.In tissues the primary location for eosinophils is in the epithelial barriers to the outside world such as, lungs, skin and GI tract.They are capable of returning to the circulating blood and bone marrow after they enter the tissues.

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Basophils as Mediators of Inflammatory Responses

Basophils serve as mediators of inflammatory responses, especially hypersensitivity reactions.IgE binds to the membrane receptors on basophils and degranulation is initiated.The enzymes released are vasoactive, bronchorestrictive and chemotactic (especially for eosinophils), so basophils seem to play a role in inducing and maintaining allergic reactions.The granules of basophils contain histamine, heparin and peroxidase.After degranulation occurs, basophils can synthesize more granules.The release of large numbers of these granules can cause anaphylactic shock and death.

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White Cell and Platelet Disorders: Peripheral Blood Clues to Nonneoplastic Conditions
The upper photograph of a peripheral blood smear reveals RBC rouleaux formation. Nucleated cells evident in both upper and lower photographs comprise approximately 5% of the total white blood cell count. The most probable underlying condition is:View Page
The association of increased platelets accompanying neutrophilia and toxic granululation as illustrated in this photograph is called thrombocythemia.View Page
Eosinophil description

The cytoplasm of eosinophils is evenly filled by numerous orange-red granules of uniform size. They do not overlie the nucleus.The eosinophil granules contain numerous enzymes including peroxidase, phospholipase D, catalase, acid phosphatase, and vitamin B12-binding proteins.Their ability to kill bacteria is less than that of neutrophils. Their main purpose is to counteract parasitic infections and to participate in immune allergic reactions.They may also be increased in a variety of nonimmunologic inflammatory responses from bacteria and fungi causing chronic infections. Malignancies, collagen vascular diseases, and myeloproliferative disorders may also may be settings for prominent eosinophils.

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A peripheral smear was submitted for morphology/clinical because of the number of monocytes as captured in the upper and lower photographs. This picture is consistent with each of the following conditions except:View Page