Inactivation Information and Courses from MediaLab, Inc.
These are the MediaLab courses that cover Inactivation and links to relevant pages within the course.
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| Defining Thalassemia Thalassemia is best thought of as a group of disorders rather than a single disease. They demonstrate a hemoglobin synthesis disorder in which there exists a defect in the rate of production of one or more of the globin chains. This defect results from either a heterozygous or homozygous deletion or inactivation of a globin chain gene. | View Page |
| Thalassemia results from | View Page |
| Defining Thalassemias Thalassemias are part of a group of hemoglobin synthesis disorders in which a defect exists in the rate of production of one or more of the globin chains. This defect results from either a heterozygous or homozygous deletion or inactivation of a globin chain gene.Thalassemias are named according to the affected gene or the globin chain that is showing reduced or absent synthesis.Globin chain loci are found on: chromosome 11 (beta, delta, epsilon, and gamma) chromosome 16 (alpha, and zeta) | View Page |
| Thalassemia results from which of the following? | View Page |
| Beta Thalassemia Minor Beta thalassemia minor (one gene mutation or deletion). This condition results in a range in beta chain synthesis from 10 - 50%. Beta thalassemia minor exists in several states that are identified with plus or zero. These notations correlate with the degree of gene deletion or inactivation.Because the delta gene is in close proximity to the beta gene, it is included in the beta thalassemia classification.The following pages include illustrations of beta thalassemia states. | View Page |
| Chromosome 11 Beta Thalassemia Intermedia B+s/B+s In Beta thalassemia intermedia, B+s/B+s, both beta chain loci show a partial deletion or inactivation of the gene.Hemoglobin A is made to only 55% to 75% of its normal amount.(drawing modified from Harmening, 1999) | View Page |