Hypogammaglobulinemia Information and Courses from MediaLab, Inc.
These are the MediaLab courses that cover Hypogammaglobulinemia and links to relevant pages within the course.
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| Unexpected positive reactions encountered during forward ABO typing may be due to: | View Page |
| ABO Antibodies and Aging ABO antibodies are not usually produced by an infant until 3 to 6 months of age. Antibodies found in the sera of newborns are almost always IgG, passively acquired from the mother. Thus, serum testing of newborns is not performed. Anti-A and anti-B titers are highest at ages 5-10 years and then they gradually decrease. Thus, in elderly patients, ABO antibodies may be difficult to detect. In patients with hypogammaglobulinemia, some leukemias, lymphomas or patients who are taking immunosuppressive drugs, the expected antibodies may be weak or even absent, reflecting the low levels of gamma globulin in the patient’s serum. As previously mentioned, these and other ABO typing discrepancies must be resolved before true ABO type can be determined. | View Page |
| There are some instances in which ABO reverse typing may be unreliable, such as in newborns, the elderly, or patients with hypogammaglobulinemia. | View Page |