Hypocellular Information and Courses from MediaLab, Inc.
These are the MediaLab courses that cover Hypocellular and links to relevant pages within the course.
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| A biopsy containing 80% fat and 20% cells would be considered: | View Page |
| Preparation of Concentrated Smears In some laboratories the anticoagulated sample is used to prepare concentrated smears. Placing the fluid in a Wintrobe tube and centrifuging it separates the sample into four layers:fat and perivascular cellsplasmabuffy layer - myeloid and nucleated erythroid cellserythrocytesThe volume of each layer is measured using the scale on the Wintrobe tube and then the percentage of each layer is calculated. Next the plasma is removed and a smear is made from the buffy coat and top of the red cell layer. Either the manual push method or cytospin technique may be used to make the smears. They may be stained with a variety of cytochemical stains. Concentrated smears are used to examine cell morphology and demonstrate the presence of abnormal cells when the marrow is hypocellular. The smears cannot be used for differential counts or evaluation of cellularity. | View Page |
| Medium Power View of Biopsy This biopsy also has a cellularity of 25% and approximately 75% fat, and is therefore slightly hypocellular. | View Page |
| Hypoplasia and Hyperplasia The terms hypoplasia and hyperplasia are synonyms for hypocellular and hypercellular. | View Page |
| Match the following: | View Page |
| The peripheral blood platelet count in this patient will likely be: | View Page |
| Hypocellular Bone Marrow Biopsy This biopsy section was taken from a patient who has very few cellular elements in the marrow. Notice that over 90% of the marrow is composed of fat. If all of the cellular elements are decreased, the patient's condition is said to be pancytopenic or aplastic. There are numerous causes for aplasia, including drugs such as chloramphenicol, chemotherapy and inheritance (Fanconi's Anemia). | View Page |
| Low Power View of Biopsy This low power view of a hematoxyln and eosin stained bone marrow biopsy shows fat cells as clear circles, and the darker intervening areas as blood cell precursors. This biopsy is about 25% cellular, or mildly hypocellular. A normal marrow in a middle aged adult is about 50% cellular. | View Page |
| Select the correct answer from the choices provided. | View Page |