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Hypersegmented neutrophil Information and Courses from MediaLab, Inc.

These are the MediaLab courses that cover Hypersegmented neutrophil and links to relevant pages within the course.

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CLIA Hematology / Hemostasis Review
Which of the following conditions is frequently associated with these cells?View Page

Red Cell Disorders: Peripheral Blood Clues to Nonneoplastic Conditions
Conditions suggested by the macrocytes and the neutrophil in the photograph to the right include:View Page
Hypersegmented Neutrophils

The focus of these photographed fields is on the occasional large oval macrocyte,and the large, hypersegmented neutrophils representing either vitamin B-12 or folic acid deficiency, or both. The distinct hypochromia of many of the erythrocytes reflects low iron stores.

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Variations in White Cell Morphology - Granulocytes
Which of the following statements are true concerning hypersegmented neutrophils:View Page
Section Overview

This exercise includes hypersegmented neutrophils, hyposegmented neutrophils and Barr bodies.

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Hypersegmented Neutrophil

A hypersegmented neutrophil showing seven segments is seen in the center of this slide.

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Another Example of a Hypersegmented Neutrophil

Another example of a hypersegmented neutrophil. This cell has six lobes. Hypersegmented neutrophils are sometimes larger than normal neutrophils. The examples shown in slides 5 and 6 are within the normal -- 12 to 15 microns in diameter.

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Which of the following statements is true for hypersegmented neutrophils? (Choose ALL of the correct answers)View Page
Which of the following are seen in Pelger-Huet anomaly? (Choose ALL of the correct answers)View Page
Hypersegmented neutrophils are classified as reactive.View Page
Conditions Associated with Hypersegmented Neutrophils

There are a number of conditions in which hypersegmented neutrophils may be seen, such as megaloblastic anemias that include folic acid deficiency and pernicious anemia. Individuals who are receiving chemotherapy or have long-term chronic infections may also have hypersegmented neutrophils.The cells seen in these conditions would be classified as pathological since the body is responding abnormally as a result of either a deficiency of a component needed for DNA production or because of the toxic effect that chemotherapy drugs have on DNA.

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A Normally Segmented Neutrophil

A normal segmented neutrophil having five lobes that was present on the same slide as the hypersegmented neutrophils.

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White Cell and Platelet Disorders: Peripheral Blood Clues to Nonneoplastic Conditions
The presence in the peripheral blood of an increased number of hypersegmented white blood cells as presented in the photograph serves as a marker for preleukemia.View Page
A most useful follow-up test to consider when faced with hypersegmented neutrophils and oval macrocytes (see photograph) in a peripheral blood smear is:View Page


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