Hypersegmentation Information and Courses from MediaLab, Inc.
These are the MediaLab courses that cover Hypersegmentation and links to relevant pages within the course.
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| The WBC indicated by the arrow in this illustration is exhibiting: | View Page |
| What is a prominent morphologic feature of lead poisoning: | View Page |
| Hypersegmentation of granulocytes is most commonly associated with: | View Page |
| A frail 85-year-old woman living in an extended care facility was found lying on the floor. Her eating habits had been irregular and food intake scanty. Her skin had tissue paper-like quality, with a pearly grey sheen. In good light a faint lemon-yellow color became evident.Her hemoglobin was 9.2 mg/dl. The peripheral blood smear (upper and lower photographs) is most consistent with: | View Page |
| Conditions suggested by the macrocytes and the neutrophil in the photograph to the right include: | View Page |
| Nuclear changes include: | View Page |
| Hypersegmentation A normal mature neutrophil is 9-13 microns in diameter and contains 3-5 lobes or segments.When the number of segments is increased to six or more the cell is hypersegmented. Some hypersegmented cells will be larger than in 15 microns. Hypersegmentation is seen most frequently in neutrophils but can also occur in eosinophils and basophils. The nuclear segments are composed of deoxyribonucleic acid (DNA). A defect in the production of DNA causes the maturation process to be slower than normal which in turn causes the nucleus to hypersegment. The cytoplasm will be normal in appearance and function, indicating that these cells are capable of phagocytosis.These cells are considered pathological | View Page |
| The presence in the peripheral blood of an increased number of hypersegmented white blood cells as presented in the photograph serves as a marker for preleukemia. | View Page |
| A most useful follow-up test to consider when faced with hypersegmented neutrophils and oval macrocytes (see photograph) in a peripheral blood smear is: | View Page |