Hmwk Information and Courses from MediaLab, Inc.
These are the MediaLab courses that cover Hmwk and links to relevant pages within the course.
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| Which coagulation pathway is initiated when collagen is exposed, and involves the substances HMWK, Fletcher Factor, and Hageman Factor? | View Page |
| Secondary Hemostasis – The Intrinsic Pathway Exposure to contact substances, such as collagen, can activate the intrinsic pathway.
The exposed collagen is the location where a complex between High Molecular Weight Kininogen (HMWK), Prekallikrein (also known as Fletcher Factor, which activates to Kallikrein), and factor XII (Hageman Factor) forms.
Together, this three biochemical complex, adhered to the collagen binding site, catalyzes the conversion of factor XII to its activated form, XIIa, thereby triggering the intrinsic pathway.
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| Secondary Hemostasis – The Intrinsic Pathway Here is where the “cascade” or “waterfall” nomenclature becomes evident as each activated factor triggers the conversion and activation of subsequent factors.
Factor XIIa, activated previously, catalyzes the conversion of factor XI into XIa, while in the presence of HMWK.
Note: This reaction can occur without HMWK, but will be much slower.
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