Histiocyte Information and Courses from MediaLab, Inc.
These are the MediaLab courses that cover Histiocyte and links to relevant pages within the course.
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| Pia Arachnoid Mesothelial Cells (continued) A reactive pia arachnoid mesothelial cell as noted by the darker cytoplasm is present in this field. Reactive cells are a common finding in cytospin smears from spinal fluid samples and are sometimes difficult to distinguish from tumor cells. Mesothelial cells are usually interspersed among the other cells, rather than appearing in clumps. They have a single distinct nuclei that may be eccentric.
The macrophages (histiocytes) are seen next to the mesothelial cell. Macrophages are distinguished from circulating monocytes by the irregular appearing cytoplasm. Bacteria, red cells or other debris can often be seen in the cytoplasm of macrophages.
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| Monocytes The arrow in this slide is pointing to a monocyte. The nucleus has an open chromatin pattern which gives it a spongy appearance. There is another monocyte in the lower right corner of the field. The other two cells could be classified as macrophages (histiocytes) because the nucleus is oval or kidney bean-shaped and the cytoplasm is very irregular. After circulating in the blood for one to three days, monocytes enter the tissues. The tissue form of the monocyte is called a macrophage or histiocyte.
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| Lymphocytes Many lymphocytes are present in this field. Two larger, atypical lymphocytes with intact cytoplasm and slightly indented nuclei are seen near the center of this slide. Two other large cells with irregular, trailing cytoplasm are macrophages (histiocytes). Increased lymphocytes may be seen in viral meningoencephalitis, partially treated bacterial meningitis, multiple sclerosis, Guillian-Barre's syndrome, or polyneuritis.
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| Neutrophils Many neutrophils are present in this slide from a spinal fluid sample from a patient with bacterial meningitis. Several macrophages (histiocytes) which have engulfed some of the bacteria can also be seen among the neutrophils. | View Page |
| Location of Cells within Cord continued Another representation of the cells in a hematopoiectic cord which focuses in the appearance of various cells as well as their location within the cord is shown here.
HC: hematopoiectic cordVS: venous sinusAdv: adventitial cellEnd: endothelial cellGP: granulopoiesisF: fat cellsEi: erythroipoietic islandHist: histiocyte (macrophage)Meg: megakaryocyteA: arteriole | View Page |
| Gaucher Cell A Gaucher cell is a histiocyte (macrophage) whose cytoplasm is filled with linear or fibrillar material (kerasin). This cell is characteristic of the congenital glycolipid disorder, Gaucher's disease. Gaucher cells may also be seen in the marrow of patients with chronic granulocytic leukemia. When seen in this condition, they are referred to as pseudo-Gaucher cells. | View Page |