Hematopoietic Information and Courses from MediaLab, Inc.
These are the MediaLab courses that cover Hematopoietic and links to relevant pages within the course.
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| Cells Seen in CSF Cells that may be seen in cerebrospinal fluid may be divided into four categories:mature peripheral blood cellsimmature hematopoietic cellstissue cellsmalignant cells
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| Immature Hematopoietic Cells The presence of blast cells or immature stages of hematopoietic cell lines are significant abnormal findings in any spinal fluid sample. However, the presence of nucleated red blood cells is the result of bone marrow contamination during the spinal tap. | View Page |
| The two main compartments of the bone marrow are the venous sinuses/blood vessels and hematopoietic cords. | View Page |
| Which of the following statements are true for the hematopoietic cords? | View Page |
| Cellular Componenets of Hematopoietic Cords The components of the hematopoietic cords include: supporting cellsfat cellshematopoietic cellsarterioles | View Page |
| Supporting Cells Reticular cells (adventitial cells) provide structural support for the endothelial cells that line the venous sinus and the developing blood cells within the hematopoietic cord. The cytoplasm of the reticular cells is capable of extending itself in fiberlike strands deep into the hematopoietic cords. These strands provide a meshwork for the blood cells. Other types of cells which furnish support in the cord include macrophages and fat cells. | View Page |
| Location of Cells within Cord Within the hematopoietic cords each cell line has a specific location for development.
Erythroid precursors are located near a venous sinusoid and cluster around a macrophage. This is referred to as an erythroblastic island. Developing red cells obtain iron needed for hemoglobin production from macrophages.
Megakaryocytes are also located close to a venous sinus. They extend their cytoplasm in fingerlike projections through the sinus wall in order to release their platelets directly into the blood in the sinus.
Immature granulocytes lie within the hematopoietic cords.
The metamyelocyte stage is the first stage of the granulocyte series that is motile and able to move toward the sinus area. Mature neutrophils, eosinophils and basophils enter the sinusoidal blood through the basement membrane. As maturing erythrocytes also move toward the sinus wall any remaining nuclei are lost as the red cells move through small openings in the cells lining the sinus wall. | View Page |
| The cells that provide support for the developing cells in the hematopoietic cords are: | View Page |
| Which of the following statements are true for the blood vessel/sinus compartment of the bone marrow? (Choose ALL of the correct answers) | View Page |
| Venous sinuses alternate with hematopoietic cords in a spokelike pattern. | View Page |
| Sinuses/Blood Vessels Circulating blood enters the bone through the central artery which branches out into small arterioles. These arterioles are interspersed in the cords of hematopoietic tissue. The arterioles drain into venous sinuses (space or cavity). Sinuses have a basement membrane which is lined by endothelial cells within the sinus and surrounded by reticular (e.g. adventitial) cells on other side. Blood from several venous sinuses may combine in a collecting sinus which leads to a central vein. The venous sinuses alternate with hematopoietic cords in a spokelike pattern with the central vein as the core. | View Page |
| The nucleated red blood cell and myelocyte photographed here were found on scanning of a peripheral blood smear. In context they are suggestive of metastatic carcinoma to the bone marrow. | View Page |