Haptoglobin Information and Courses from MediaLab, Inc.
These are the MediaLab courses that cover Haptoglobin and links to relevant pages within the course.
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| Serum Chemistry Results Test Results Reference Ranges Serum iron 250 g/dL 26 -170 g/dL Iron binding capacity 130 g/dL 250 - 400 g/dL Bilirubin (unconjugated) 2.6 mg/dL 0.2 - 1.0 mg/dL Lactate dehydrogenase 320 U/L 100 - 190 U/L Haptoglobin 52 mg/dL 40 - 330 mg/dL | View Page |
| Serum Haptoglobin Haptoglobin is the plasma protein responsible for binding free hemoglobin during episodes of hemolysis and would normally demonstrate decreased levels during a hemolytic crisis.The normal level of haptoglobin is 40-330mg/dl. Individuals who are in hemolytic crisis demonstrate greatly reduced levels to an absence of haptoglobin.In alpha thalassemia, however, haptoglobin levels remain normal or only slightly decreased, even during hemolytic events.The reason for this is that haptoglobin functions by binding the alpha chain portion of hemoglobin. With the absence of these chains in alpha thalassemia major and intermedia, haptoglobin cannot bind free hemoglobin. Therefore it is not consumed. | View Page |
| Clinical Significance No blood is found in the urine of healthy individuals although samples from menstruating females, frequently, but not always, test positive for blood. Hematuria is associated with renal or genital urinary disorders in which the bleeding is the result of irritation to the involved organs or trauma. Examples include renal calculi, pyelonephritis, glomerulonephritis, tumors, trauma or exposure to toxic chemicals or drugs and/or strenuous exercise. Hemoglobinuria may be due to the lysis of red cells within the urinary tract. If it is caused by intravascular hemolysis, the hemoglobin is then filtered through the glomeruli. In the normal individual, the hemoglobin molecule attaches to haptoglobin and in this way bypasses the kidney filtration system. When the hemoglobin/haptoglobin system is overwhelmed, as in cases of hemolytic anemia, severe burns, transfusion reaction, infection or strenuous exercise, hemoglobin passes into the urine. | View Page |
| Which of the following will give the best overall picture of a patient's iron stores: | View Page |