Gentamicin Information and Courses from MediaLab, Inc.
These are the MediaLab courses that cover Gentamicin and links to relevant pages within the course.
Learn more about laboratory continuing education for medical technologists to earn CE credit for AMT, ASCP, NCA, and state license renewal and recertification. Or get information about laboratory safety and compliance courses that deliver cost-effective OSHA safety training and continuing education to your laboratory's employees.
| Extended Spectrum Beta Lactamases In follow-up to the observations of the ESBL screening test, the following antibiotic susceptibility profile was later reported:
Ampicillin = R;
Cefazolin = R;
Cefoxitin 1 = S;
Ciprofloxacin 0.25 = S;
Gentamicin 1 = S;
Ceftazidime 32 = R;
Imipenem The susceptibility of the 2nd generation drug cefoxitin, with resistance of the 1st generation cefazolin and the 3rd generation ceftazidime, is another way in addition to the screening test in which ESBL activity may be detected.
It is recommended that clinical microbiologists check the antibiotic susceptibility profiles for possible ESBL activity of clinically significant isolates of K. pneumoniae and E. coli.Most automated systems have built in methods for automatically detecting an ESBL isolate, or provide an "alert" that such a strain may be present. | View Page |
| Steady State Example If the drug Gentamicin has an elimination half-life of 12 hours and is given every 12 hours, the drug should reach steady state after 5 half-lives (60 hours). Notice in the diagram that this kind of dosing results in a 'sawtooth' pattern. Peaks correspond to the times right after the drug is taken; troughs correspond to the times right before the next dose. | View Page |
| TDM for Antibiotics Infection is obviously a very serious indication, and effective antibiotic levels must be achieved as soon as possible. However, many antibiotics also have nephrotoxic or ototoxic effects; the concentrations of these antibiotics need to be monitored. Examples of antibiotics that are monitored by TDM include: Amikacin Gentamicin Tobramycin VancomycinAntibiotics such as ampicillin that are readily cleared and have a wide therapeutic window are not usually monitored by TDM. | View Page |