Genotypic Information and Courses from MediaLab, Inc.
These are the MediaLab courses that cover Genotypic and links to relevant pages within the course.
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| Normal Chromosome 16 Chromosome 16 contains the genetic codes for the zeta and alpha hemoglobin chains.Each chromosome has two loci alpha chains 1 and 2. This equals a total of four loci of material coding for the alpha hemoglobin chain. See the image for a visual representation of these loci.In the genotypic notation of alpha thalassemia an "" represents the presence of an alpha locus. A "-" represents a deletion of a locus.The notation for the normal number of alpha loci is /. The amount of Hb A produced by this normal gene is 97-98 %.(drawing modified from Harmening, 1999) | View Page |
| Match alpha thalassemia variants with their genotypic notation. | View Page |
| Normal Chromosome 11 Beta chain synthesis is controlled by two gene loci; one on each of chromosome 11. Chromosome 11 also carries the gene loci for delta chains, G-gamma and A-gamma chains and embryonic epsilon chains. Normal chromosome 11 is depicted in the image below. In the genotypic notation of beta thalassemia, a "+" represents a reduction in beta chain production whereas a "0" represents a complete deletion of a locus. The "+s" represents a silent carrier. Delta chain deletions may be present in combination with beta chain deletions.(drawing modified from Harmening, 1999) | View Page |
| Punnett Squares All possible genotypic matings for two A individuals: AA x AA A A A AA AA A AA AA AO x AA A O A AA AO A AA AO AO x AO A O A AA AO O AO OO | View Page |