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Fletcher Information and Courses from MediaLab, Inc.

These are the MediaLab courses that cover Fletcher and links to relevant pages within the course.

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Laboratories Individuals

CLIA Hematology / Hemostasis Review
Match clotting factor with its commonly associated name:View Page
Which of the following factors is not involved in the initial contact phase of the intrinsic pathway:View Page

Fundamentals of Hemostasis
Which coagulation pathway is initiated when collagen is exposed, and involves the substances HMWK, Fletcher Factor, and Hageman Factor?View Page
Secondary Hemostasis – The Intrinsic Pathway

Exposure to contact substances, such as collagen, can activate the intrinsic pathway. The exposed collagen is the location where a complex between High Molecular Weight Kininogen (HMWK), Prekallikrein (also known as Fletcher Factor, which activates to Kallikrein), and factor XII (Hageman Factor) forms. Together, this three biochemical complex, adhered to the collagen binding site, catalyzes the conversion of factor XII to its activated form, XIIa, thereby triggering the intrinsic pathway.

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