Dysplastic Information and Courses from MediaLab, Inc.
These are the MediaLab courses that cover Dysplastic and links to relevant pages within the course.
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| The cells included in the composite image were found in a peripheral blood smear with a total WBC of 24,500/mm3. The differential count was:
myelocytes 1
metamyelocytes 4
band neutrophils 15
segmented neutrophils 40
monocytes 8
eosinophils 2
basophils 1
lymphocytes 29.
This hematologic picture is most consistent with: | View Page |
| Basophils A basophil and a small lymphocyte are compared in the same field of the upper photograph, A single basophil is shown in the lower photograph.The cytoplasmic granules of the basophil are larger than the granules of toxic granulation.They contain chemical mediators of immediate hypersensitivity, and are found in the cytoplasm and overlying the nucleus (better seen in the lower photograph). Basophilic granules stain metachromatically with toluidine blue indicating the presence of acid mucopolysaccharide or proteoglycans, both thought to be heparin or heparin-like substances.Basophils are related to tissue mast cells, each involved in hypersensitivity responses and following anaphylactic episodes.Under the stimulation of complement components C3a and C5a, many mediators are released from the basophil granules, including histamine, heparin, and eosinophil chemotactic factors of anaphylaxis, or ECF-A.Basophils are the least common neutrophils in the peripheral blood, comprising 2% or less of the differential count.The presence of large granules of irregular size in basophils and the admixture of eosinophilic granules may indicate dysplastic changes associated with myelodysplastic disorders and leukemia. | View Page |
| The cell photographed here is known as a MOTT cell. The condition in which these cells are associated is: | View Page |