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Cuboidal Information and Courses from MediaLab, Inc.

These are the MediaLab courses that cover Cuboidal and links to relevant pages within the course.

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The Urine Microscopic: Microscopic Analysis of Urine Sediment
Cells which may be difficult to differentiate from WBCs are:View Page
The sediment from a freshly collected urine specimen is examined microscopically. In addition to bacteria, what other finding from the list below would further indicate the presence of a urinary tract infection (UTI)?View Page
Renal Epithelial Cells of Collecting Duct Origin

Another form of renal epithelial cells originates in the collecting ducts and measures 12-20 microns. These are identified by their characteristic cuboidal shape and large usually slightly eccentric nucleus. Cuboidal cells are sometimes confused with neutrophils. Neutrophils, however, are slightly larger to nearly twice as large (20-35 microns) as cuboidal cells and have a segmented or band-shaped nucleus while cuboidal cells have a single round nucleus. This view under high power phase contrast shows two cuboidal cells lying between squamous cells.

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Cuboidal Cells

Increased numbers of cuboidal cells are found in renal transplant rejection, acute tubular necrosis (diuretic phase), injuries that interrupt blood flow to the kidney, and acute glomerulonephritis accompanied by tubular damage. Ingestion of various drugs and chemicals may cause significant tubular shedding of these epithelial cells. Cuboidal cells are easily seen in urine in cases of salicylate intoxication.

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Renal Epithelial Fragments

Renal epithelial fragments of collecting duct origin are composed of three or more cuboidal cells. These fragments indicate a more severe form of renal tubule injury with basement membrane disruption. Proximal and distal convoluted tubule renal epithelial cells are not found in fragment form. In addition to the indication of severe tubule damage, proper identification of these fragments is important to avoid a false positive diagnosis of low-grade transitional cell carcinoma. Transitional cell carcinoma is a type of cancer seen in 71% of cases of malignant tumors of the ureter.

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The different types of epithelial cells include:View Page
A 10% solution of acetic acid can be used to differentiate what from red blood cells?View Page
White Blood Cells versus Cuboidal Epithelium

In this field there is a combination of white blood cells and cuboidal epithelium. Enumeration is difficult because of the similarity of the cells.

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White Blood Cells versus Cuboidal Epithelium

A drop of dilute acetic acid enhances the nuclear detail of the white blood cells making them much easier to distinguish from the epithelial cells.

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