Crossmatched Information and Courses from MediaLab, Inc.
These are the MediaLab courses that cover Crossmatched and links to relevant pages within the course.
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| Case Study - Case 4 A 72 year old male with a previous history of a cold antibody is in the ICU with an abdominal aortic aneurysm. The doctor has ordered 8 units of packed red cells to be crossmatched at all times for this patient.The patient's ABO/Rh is B positive.The current antibody screen is positive in both the immediate spin phase and the AHG phase.Anagram resultsResults of the anagram show the presence of an antibody that reacts at immediate spin and AHG. Because Screen cell 1 is negative at the IS phase and positive at AHG, there are possibly multiple antibodies present (IgM and IgG).Antibody PanelSelected Cell Panel 1Enzyme PanelSelected Cell Panel 2 | View Page |
| Case Presentation Mr. R.M., a 55-year old male, was admitted to a hospital emergency department with severe lower gastrointestinal bleeding. His history revealed multiple prior transfusions, the last of which he received five years earlier.Physical examination revealed hemodynamic instability (systolic BP 60 mmHg). Blood tests revealed a hemoglobin (Hb) of 8 g/dL (80 g/L) and a hematocrit (HCT) of 28% (0.28). The patient received aggressive fluid resuscitation with Ringer's lactate and was sent to the operating room (OR) for an emergency laparotomy.The physician ordered four units of Red Blood Cells to be crossmatched.Two units of uncrossmatched group O Rh-negative Red Blood Cells were also ordered and authorized for immediate emergency transfusion. | View Page |
| Antigen phenotyping results The patient's pretransfusion red cells and all donor red cells involved in the case (two group O Rh-negative RBC and four group O Rh-positive red cells initially crossmatched) were phenotyped for Jka.As expected, the patient typed as Jk(a-). The six donor RBC that were incompatible in the initial crossmatch were Jk(a+).The frequency of the Jka gene in Caucasians is ~77%, with most Caucasian red cells (50%) typing as Jk(a+b+). | View Page |