Codocyte Information and Courses from MediaLab, Inc.
These are the MediaLab courses that cover Codocyte and links to relevant pages within the course.
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| The underlying condition where the defective erythrocytes marked by arrows are of diagnostic importance is: | View Page |
| Leptocytes and target cells The peripheral blood smear of HbH disease presented before is reviewed in the upper photograph.As mentioned, these leptocytes are pale-staining with hemoglobin confined to a thin, flat, cell membrane.Illustrated in the lower photograph are target cells or codocytes (a term derived from a Greek word for hat)Membrane accumulations of phospholipids and cholesterol (particularly in obstructive jaundice) promote target cell formation.When these cells are spread out on a glass slide, a central bump of hemoglobin appears to produce the target, a manifestation of excess cellular membrane compared to the amount of hemoglobin inside.The early descriptions of thalassemias, then called hereditary leptocytosis (Mediterranean anemia, Cooley's anemia), include description of leptocyes, which may have represented HbH disease. | View Page |
| Which of the following terms could be used to describe the cell in the center of the field? | View Page |
| The cell in the center of this slide is a/an: | View Page |
| Which of the following forms is seen in this field? | View Page |
| Synonyms for Codocytes Synonyms for a Codocyte include target cell, Mexican hat cell, and Leptocyte(thin). | View Page |
| Match the following terms with their synonyms. | View Page |
| The abnormal form seen in the center of this slide is: | View Page |
| The three cells in the center of this field are: | View Page |
| The cell in the center of this field is a/an: | View Page |
| Codocyte Target cells are thin-walled cells showing a darkly-stained center area of hemoglobin which has been separated from the peripheral ring of hemoglobin. When viewed under the electron microscope. these cells have a cup-shaped appearance. A codocyte is seen in the center of this slide. | View Page |
| Another Target Cell Another example of a target cell (or codocyte) is seen in the center of this slide. Notice that the hemoglobin in the center of this cell is somewhat lighter in appearance than in the previous slide. A second codocyte can be seen in the upper left portion of the slide. Codocytes appear in conditions which cause the surface of the red cell to increase disproportionately to its volume. This may result from a decrease in hemoglobin, as in iron deficiency anemia, or an increase in cell membrane.
Target cells have excess membrane cholesterol and phospholipid and decreased cellular hemoglobin. Examples of other conditions in which target cells may be present include thalassemias, hgb C disease, post splenectomy and obstructive jaundice. Since their presence can be the result of an in vitro artifact, their value in clinical diagnosis is limited. | View Page |
| The predominant abnormal forms seen in this slide are: | View Page |