Chediac-higashi Information and Courses from MediaLab, Inc.
These are the MediaLab courses that cover Chediac-higashi and links to relevant pages within the course.
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| Select the letter representing the cell that may be seen in increased numbers in the peripheral blood smear in immediate hypersensitivity reactions: | View Page |
| Chediac-Higashi anomaly In 1952 Chediak (a Cuban physician) reported a childhood disorder in which abnormal cytoplasmic inclusions appeared in the neutrophils of four family members. In 1954 Higashi reported a similar abnormality in an 11-month old Japanese infant. These inclusions were identified as lysosomal in origin and found in this rare autosomal recessive disorder Death was usually related to recurrent infections or hemmorhage though now some of the affected patients live to reproduce. Ocular and cutaneous albinism, increased susceptibility to pyogenic infections, abnormal granules in neutrophils, and a bleeding tendency are prominent findings. The striking neutrophilic inclusions appear as coarse intra-cytoplasmic azurophilic granules (see photograph).These granules arise from dilated portions of the Golgi-endoplasmic reticulum lysosomal apparatus. Aleutian mink and other animals are known to have Chediak-Higashi syndrome. Azurine pelts from infected mink were once prized by coat makers. | View Page |
| The granulated neutrophil shown in the photograph may be found in each of the following conditions except: | View Page |