Ceftazidime Information and Courses from MediaLab, Inc.
These are the MediaLab courses that cover Ceftazidime and links to relevant pages within the course.
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| ESBL Activity Illustrated is the picture of the surface of a disk diffusion test including a ceftazidime disk (left) and a combintation ceftazidime/clavulanic acid disk (right).Observe in the photograph that the zone of inhibition around the the combination ceftazidime/clavulanic acid disk (right) is at least 5 mm larger than around the clavulanic acid disk (left).This observation that the presence of clavulanic acid, a beta-lactamase inhibitor, has resulted in such a large increase in the zone of inhibition indicates that an extended spectrum beta lactamase (ESBL)is being produced.When an organism is producing an ESBL, the susceptibility to individual cephalosporins cannot be predicted, thus requiring that each drug must be tested individually.It may be important to detect ESBL-producing stains of K. pneumoniae and E. coli as treatment failure may occur if the wrong cephalosporin is selected. | View Page |
| Extended Spectrum Beta Lactamases In follow-up to the observations of the ESBL screening test, the following antibiotic susceptibility profile was later reported:
Ampicillin = R;
Cefazolin = R;
Cefoxitin 1 = S;
Ciprofloxacin 0.25 = S;
Gentamicin 1 = S;
Ceftazidime 32 = R;
Imipenem The susceptibility of the 2nd generation drug cefoxitin, with resistance of the 1st generation cefazolin and the 3rd generation ceftazidime, is another way in addition to the screening test in which ESBL activity may be detected.
It is recommended that clinical microbiologists check the antibiotic susceptibility profiles for possible ESBL activity of clinically significant isolates of K. pneumoniae and E. coli.Most automated systems have built in methods for automatically detecting an ESBL isolate, or provide an "alert" that such a strain may be present. | View Page |