Cardiac Biomarkers (Online Course)
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Author: Mary Ellen Koenn, MS, MT(ASCP), CLS(NCA)
Reviewer: Leslie Lovett, MS, MT(ASCP)
Each year in the US alone, over one million individuals are diagnosed with an acute myocardial infarction (AMI) and approximately one half of these have had an AMI in the past. However, as many as 1 - 5% of patients with an AMI are misdiagnosed in the emergency department and are discharged. Rapid diagnosis of acute myocardial infarction is vital and laboratory testing that is sensitive and specific is essential. Upon completion of this course, you will be able to identify the characteristics of an optimal cardiac biomarker and discuss the laboratory tests that are most useful for rapid diagnosis and monitoring of ischemic heart disease and heart failure.
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Continuing Education Credits
- P.A.C.E.® Contact Hours: 1.5 hour(s)
- Florida Board of Clinical Laboratory Science CE - General (Clinical Chemistry/UA/Toxicology): 1.5 hour(s)
Objectives
- Describe the role of cardiac biomarkers, the characteristics of a good marker of cardiac disease, and the use of cardiac biomarkers today.
- Explain atherosclerosis as an inflammatory process.
- Compare and contrast the cardiac biomarkers cTnI and cTnT.
- Discuss the utilization of CK-MB, myoglobin, and CK-isoform measurement in diagnosis of an acute myocardial infarction.
- Describe the formation of BNP and NT-ProBNP and their role as markers of congestive heart failure.
- Interpret the measurement results of cardiac biomarker assays in the diagnosis of an acute myocardial infarction and congestive heart failure.
- Explain the utilization of new screening markers for cardiovascular disease and acute coronary syndromes: hs-CRP, homocysteine, ischemia modified albumin, and myeloperoxidase.
- Explain the role of cardiac biomarkers in risk stratification of those with heart disease.
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Course Outline
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- Cardiac and Vascular Disease
- Biomarkers of Cardiac Disease
- Heart Disease and Cardiac Biomarkers
- Uses of Cardiac Biomarkers
- Optimal Cardiac Biomarkers
- Current Cardiac Biomarkers
- Biomarkers of An AMI
- History
- Troponins
- cTnI
- cTnT
- Use of Troponins
- cTnI Versus cTnT
- Troponin Measurement and Ranges
- Select the correct statements regarding troponins.
- CK-MB
- CK-MB Measurement and Ranges
- Myoglobin
- CK-Isoforms
- Diagnosis of an Acute Myocardial Infarction (AMI)
- Pattern of AMI Biomarker Levels
- 2007 Guidelines for Cardiac Markers in AMI Diagnosis
- Biomarker Sampling Guidelines
- Which ones of the following cardiac biomarkers can be used as a stand-alone marker, and is therefore the preferred biomarker to indicate the presence ...
- Which one of the following cardiac biomarkers could detect a reinfarction?
- A 62-year-old male has been brought by ambulance to the emergency department. The patient is a smoker with a history of uncontrolled hypertension. Whi...
- While driving home after work, a 45-year-old male construction worker is involved in a collision with another car. Upon arrival in the emergency depar...
- Biomarkers in CHF
- Cardiac Biomarkers and Congestive Heart Failure
- Function of BNP
- BNP Versus NT-ProBNP
- BNP and NT-ProBNP Measurement and Ranges
- What is the function of the hormone, BNP?
- A 79-year-old diabetic and retired homemaker lives alone since the death of her husband 5 years ago. At age 75, she was diagnosed with an AMI and had ...
- Risk Stratification and Cardiac Biomarkers
- Biomarkers to Identify Those at Risk for Developing Cardiac Disease
- Screening Biomarkers
- High Sensitivity C-Reactive Protein (hs-CRP)
- Use of hs-CRP, Measurement, and Ranges
- Homocysteine
- Ischemia Modified Albumin (IMA)
- Myeloperoxidase
- Future Cardiac Biomarkers
- Which biomarkers of cardiac disease risk are inflammatory markers?
- Comparisons of Concentrations of CRP and hs-CRP
- Comparisons of Concentrations of CRP and hs-CRP
- References
Additional Information
Level of instruction: Intermediate
Intended Audience: Clinical laboratory technologists and technicians, and other health care personnel who have an interest in this subject matter. This course is also appropriate for medical laboratory science students and pathology residents. Author information: Mary Ellen Koenn, MS, MT(ASCP), CLS(NCA) is an associate professor at West Virginia University School of Medicine in the Medical Technology Program. During her career as a medical technologist and educator, she has been a laboratory supervisor and manager and has held several teaching positions. She is active in the American Society for Clinical Laboratory Science (ASCLS), resulting in a nomination as ASCLS Member of the Year in 2006. She is also a member of the American Association for Clinical Chemistry. She is the author of numerous articles for laboratory publications and textbook chapters and is a frequent presenter at laboratory seminars and workshops. Ms. Koenn holds a Master of Science degree in Medical Technology. Reviewer information: Leslie Lovett, MS, MT(ASCP) is the Clinical Education Coordinator of the Medical Laboratory Technology Program and a professor at Pierpont Community and Technical College in West Virginia. She holds a MS degree in Medical Technology with classes toward a PhD in Pharmacology and Toxicology.
Course Description: This course discusses the many types and applications of electrophoresis in the clinical laboratory. Commonly used terms are defined and procedures are described, including explanations of various electrophoretic patterns. A discussion on newer molecular diagnostic techniques that incorporate electrophoresis conclude this in depth look at electrophoresis.
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