Bilobed Information and Courses from MediaLab, Inc.
These are the MediaLab courses that cover Bilobed and links to relevant pages within the course.
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| Pelger-Huet anomaly is characterized by: | View Page |
| Which of the following statements are true for hyposegmented neutrophils: | View Page |
| Bilobed Neutrophil This slide shows an example of bilobed neutrophil, often referred to as the pince-nez form. Pince-nez means spectacle in French. | View Page |
| Hyposegmentation of Neutrophils Hyposegmented cells are neutrophils with fewer than three nuclear lobes. The nucleus may be round, peanut-shaped, band-shaped or bilobed. Since nuclear lobe development is abnormal, the chromatin structure often appears more mature than normal. It is sometimes very smooth, almost pyknotic. | View Page |
| Pelger-Huet Anomaly Pelger-Huet anomaly is the inherited form of neutrophilic hyposegmentation. Its transmittance is autosomal dominant and the anomaly is present in one out of 6000 people. When present, all of the neutrophils will be hyposegmented; however, the homozygous state will have increased number of cells with singular round nucleus and decreased numbers of the bilobed forms. | View Page |
| Pelger-Huet Cells The band-shaped form seen in the center of this field is typical of the bilobed cells seen in Pelger-Huet. Notice the chromatin structure is almost smooth in appearance, showing little parachromatin. Normal bands have more clumping in the chromatin pattern. | View Page |
| A large percentage of the neutrophils on the peripheral blood smear of a young man are similar to those in the photograph.They most likely represent what condition: | View Page |
| Pelger-Huet Anomaly The Pelger-Huet anomaly is a congenitally acquired condition of nuclear segmentation and is clinically insignificant. There is no loss of cellular function.The condition can be suspected if typical bilobed, "pince-nez" nuclei are observed (left upper frame in the composite photograph).Band neutrophils usually have two distinct lobes, connected by a relatively short but thick bridge as illustrated in the upper and lower right frames. Monolobated cells may also be encountered, as illustrated in the lower left frame. If these are seen in significant numbers, the possibility of a homozygous Pelger-Huet should be considered. | View Page |