Barr bodies Information and Courses from MediaLab, Inc.
These are the MediaLab courses that cover Barr bodies and links to relevant pages within the course.
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| Nuclear changes include: | View Page |
| Barr bodies are usually classified as: | View Page |
| A patient has a WBC count of 4,000/mm3, platelet estimation is 3 bizarre platelets/oil immersion field, hemoglobin, hematocrit, red cell count and indice values are within normal limits. Blue staining inclusions are seen in the cytoplasm of many neutrophils. These inclusions fit the description of: | View Page |
| What morphological change is present in this slide? | View Page |
| What morphological change is present in this slide? | View Page |
| Section Overview This exercise includes hypersegmented neutrophils, hyposegmented neutrophils and Barr bodies. | View Page |
| Barr Body A Barr body appears as a small drumstick-like projection on one of the lobes of a some of the neutrophil in females. Barr bodies are attached to the nuclear lobe by a single narrow stalk which distinguishes them from other thicker projections, sometimes referred to as "clubs." Clubs have a thicker, and sometimes, a double stalk. This projection can be seen in both males and females and has no clinical significance. Barr bodies must also be distinguished from hair-like projections sometimes seen in the band form, following irradiation or in patients with a malignant tumor that has metastasized. Since Barr bodies are the morphological expression of the inactivated X chromosome, one Barr body can be seen in up to 3% of the neutrophils on a female's peripheral blood slide. In rare chromosome disorders in which three or more X chromosomes are present, two to three Barr bodies per neutrophil can be seen. Recognition of a Barr body in a neutrophil is important in order to avoid reporting it as abnormal unless two or more per neutrophil are seen. | View Page |
| Barr Bodies may be Normal or Pathological The Barr body is considered nonpathological unless associated with the rare chromosome disorders, in which case it would be pathological. | View Page |
| Choose ALL of the answers that correctly complete the following statement: Barr bodies are important to recognize because they | View Page |
| Barr bodies are classified as pathological, nonpathological, and reactive. | View Page |