Alder-reilly Information and Courses from MediaLab, Inc.
These are the MediaLab courses that cover Alder-reilly and links to relevant pages within the course.
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| The WBC anomaly indicated by the arrow in this illustration is: | View Page |
| Abnormal granulation can be seen in the cytoplasm leukocytes in which of the following conditions: | View Page |
| What morphological change is present in this slide? | View Page |
| What morphological change is present in this slide? | View Page |
| What morphological change is present in this slide? | View Page |
| What morphological change is present in this slide? | View Page |
| Alder-Reilly Anomaly This slide is also from a patient who has Alder-Reilly anomaly. Notice that neutrophil seen in this slide has granulation which is much heavier than in the previous slide. The amount of granulation may vary from cell to cell with some cells being unaffected. A lymphocyte showing abnormal granules is also present in this slide. | View Page |
| Auer rods are significant when they are seen in the cytoplasm of blast cells because they are diagnostic for: | View Page |
| Alder-Reilly is characterized by: | View Page |
| Which morphologic term describes this slide? | View Page |
| Which morphologic term describes this slide? | View Page |
| Alder-Reilly Neutrophil An example of a normal neutrophil, lower left, and one showing some increased granulation typical of that seen in Alder-Reilly anomaly. Morphologically, it may be difficult to distinguish these granules from toxic granulation, however, the diagnosis is made on the basis of the presence of the many distinctive physical characteristics. | View Page |
| Alder-Reilly Anomaly (Alder's Anomaly) Alder Reilly Anomaly is a rare autosomal recessive hereditary disorder in which the basic defect involves protein-carbohydrate complexes called mucopolysaccharides. The accumulation of partially degraded (broken down) protein-carbohydrate complexes within the lysosomes account for the larger than normal purple-staining granules seen in the granulocytes, monocytes and/or lymphocytes.
The granules may occur in clusters, rather than diffusely, throughout the cytoplasm as in toxic granulation.
These inclusions may be seen in the bone marrow more frequently than in peripheral blood. The physical characteristics associated with this disorder include gargoylism and dwarfism.
The function of the cells involved is not affected.
This morpholical change would be classified as pathological since the body is responding abnormally even though the function is not affected. | View Page |
| Match each of the following. Answers may be used more than once or not at all. | View Page |
| Which morphologic term describes this slide? | View Page |
| Which morphologic term describes this slide? | View Page |
| Atypical neutrophilic intra-cytoplasmic inclusions ,as noted in the photograph, are present in a peripheral blood smear when one or more of the following underlying conditions are present: | View Page |
| Alder- Reilly Anomaly Large inclusions in leukocyte cytoplasm appear with Alder-Reilly syndrome. Inheritance patterns are not completely clear. The condition is characterized by larger than usual azurophilic and deeply violet staining granules clustered throughout the cytoplasm (even covering the nucleus)in all granulocytes. There are variations in which some lymphocytes and monocytes may be affected. These inclusions represent partially degraded mucopolysaccharides within lysosomes.Alder-Reilly bodies may be found independently of genetic mucopolysaccharidoses as an inherited anomaly (Jordan's anomaly). Cytoplasmic vacuoles of toxic origin are not present in Alder-Reilly cells. The background condition in Alder-Reilly syndrome is mucopolysaccharidosis with various types of bone and cartilage disorders, reported first in gargoylism, then in Hunter and Hurler syndromes. Accompanying conditions are hepatosplenomegaly, corneal opacities, and mental retardation. Reference: Brunning, Richard D. Morphologic Alterations in Nucleated Blood and Marrow Cells in Genetic Disorders. Human Pathol: 99-124, March, 1970 | View Page |
| WBC inclusions: summary The presence of atypical inclusions within the cytoplasm of neutrophils and other leukocytes should lead to a clinical investigation of the setting for these findings.Atypical neutrophil inclusions may be seen in the following disorders: Chediak-Higashi syndrome, May-Hegglin anomaly, Alder-Reilly anomaly, Fechtner , Sebastian, Epstein and Alport-like syndromes and in infectious and toxic conditions (in the form of Doehle bodies).Although a specific entity may not be evident from examination of the peripheral blood alone, it is important that hematology technologists include a comment reporting on the presence of these inclusions or granules. A clinical investigation with further hematologic and genetic studies may then appropriately be considered.Many of the disorders with atypical neutrophil cytoplasmic granules are also associated with platelet abnormalities, particularly giant platelets (lower photograph).Therefore, when atypical granules are recognized, scanning of the peripheral blood smear for atypical platelets may be revealing. These observations serve as readily identifiable markers for acquired and genetic human maladies, and as a guide for unraveling the reasons for a patient's suffering and impaired health. | View Page |