Albinism Information and Courses from MediaLab, Inc.
These are the MediaLab courses that cover Albinism and links to relevant pages within the course.
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| Alder-Reilly is characterized by: | View Page |
| Albinism Albinism, one of the striking physical characteristics of Chediak-Higashi syndrome, is also thought to be related to the general dysfunction of cells. Albinism has been specifically related to the aggregation of melanosomes, the pigment producing cells in the body. | View Page |
| Match the letters representing the peripheral white blood cells with the most likely associated clinical conditions. | View Page |
| Assuming that other circulating neutrophils are similar to the band neutrophil in the photograph(see inclusion at arrow tip), which of the following conditions is most likely? | View Page |
| Atypical neutrophilic intra-cytoplasmic inclusions ,as noted in the photograph, are present in a peripheral blood smear when one or more of the following underlying conditions are present: | View Page |
| Chediac-Higashi anomaly In 1952 Chediak (a Cuban physician) reported a childhood disorder in which abnormal cytoplasmic inclusions appeared in the neutrophils of four family members. In 1954 Higashi reported a similar abnormality in an 11-month old Japanese infant. These inclusions were identified as lysosomal in origin and found in this rare autosomal recessive disorder Death was usually related to recurrent infections or hemmorhage though now some of the affected patients live to reproduce. Ocular and cutaneous albinism, increased susceptibility to pyogenic infections, abnormal granules in neutrophils, and a bleeding tendency are prominent findings. The striking neutrophilic inclusions appear as coarse intra-cytoplasmic azurophilic granules (see photograph).These granules arise from dilated portions of the Golgi-endoplasmic reticulum lysosomal apparatus. Aleutian mink and other animals are known to have Chediak-Higashi syndrome. Azurine pelts from infected mink were once prized by coat makers. | View Page |