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Adventitial Information and Courses from MediaLab, Inc.

These are the MediaLab courses that cover Adventitial and links to relevant pages within the course.

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Introduction to Bone Marrow
Which of the following statements are true for the hematopoietic cords?View Page
Supporting Cells

Reticular cells (adventitial cells) provide structural support for the endothelial cells that line the venous sinus and the developing blood cells within the hematopoietic cord. The cytoplasm of the reticular cells is capable of extending itself in fiberlike strands deep into the hematopoietic cords. These strands provide a meshwork for the blood cells. Other types of cells which furnish support in the cord include macrophages and fat cells.

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The cells that provide support for the developing cells in the hematopoietic cords are:View Page
Location of Cells within Cord continued

Another representation of the cells in a hematopoiectic cord which focuses in the appearance of various cells as well as their location within the cord is shown here. HC: hematopoiectic cordVS: venous sinusAdv: adventitial cellEnd: endothelial cellGP: granulopoiesisF: fat cellsEi: erythroipoietic islandHist: histiocyte (macrophage)Meg: megakaryocyteA: arteriole

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Sinuses/Blood Vessels

Circulating blood enters the bone through the central artery which branches out into small arterioles. These arterioles are interspersed in the cords of hematopoietic tissue. The arterioles drain into venous sinuses (space or cavity). Sinuses have a basement membrane which is lined by endothelial cells within the sinus and surrounded by reticular (e.g. adventitial) cells on other side. Blood from several venous sinuses may combine in a collecting sinus which leads to a central vein. The venous sinuses alternate with hematopoietic cords in a spokelike pattern with the central vein as the core.

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