Adsorption Information and Courses from MediaLab, Inc.
These are the MediaLab courses that cover Adsorption and links to relevant pages within the course.
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| Proteins Involved in Adsorption The joining of the HIV and the host cell involves a spike on the HIV envelope and a CD4 molecule on the T-lymphocyte, macrophage, or brain cell.The molecule on the HIV spike is called glycoprotein 120 or gp120. The "120" refers to the molecular weight of the glycoprotein.While the CD4 site is important in viral binding, there is evidence that there are other molecules called co-receptors also involved.These molecules are embedded in the membranes of T-lymphocytes, macrophages, and brain cells. In the T-lymphocyte the abbreviated name of the protein molecule is CXCR4. | View Page |
| The stage of viral replication where the envelope is being acquired and the HIV is leaving the host cell is known as: | View Page |
| Adsorption (2) Once the gp120 drops down and binds with CD4 and the co-receptor, the HIV spike is exposed.The spike is a glycoprotein with a molecular weight of 41 Kilodaltons. This gp41 molecule acts much like a spring-loaded lancet. Once triggered into action by the attachment of the gp120 to the CD4 and co-receptor, the gp41 springs out and pierces the membrane of the host cell. | View Page |
| Proteins Involved in Adsorption The joining of the HIV and the host cell involves a spike on the HIV envelope and a CD4 molecule on the T-lymphocyte, macrophage, or brain cell.The molecule on the HIV spike is called glycoprotein 120 or gp120. The "120" refers to the molecular weight of the glycoprotein.While the CD4 site is important in viral binding, there is evidence that there are other molecules called co-receptors also involved.These molecules are embedded in the membranes of T-lymphocytes, macrophages, and brain cells. In the T-lymphocyte the abbreviated name of the protein molecule is CXCR4. | View Page |
| Adsorption (1) While more research is needed to confirm the sequence, it is believed that the gp120 molecule on the HIV unites, via the V3 loop, with the CD4 molecule on the T-lymphocyte, macrophage, or brain cell.The gp120 then changes shape, drops down, and binds with the co-receptor.Thus HIV binds twice to the T-lymphocyte or macrophage - once at the CD4 molecule and once at the co-receptor site. | View Page |