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Abetalipoproteinemia Information and Courses from MediaLab, Inc.

These are the MediaLab courses that cover Abetalipoproteinemia and links to relevant pages within the course.

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CLIA Hematology / Hemostasis Review
The abnormal RBC shape seen in this illustration is:View Page

Red Cell Disorders: Peripheral Blood Clues to Nonneoplastic Conditions
Match the red cell shapes in each frame of the photograph with its most likely corresponding clinical condition.View Page
The peripheral blood picture is consistent with each of the following conditions except:View Page
The underlying condition where the defective erythrocytes marked by arrows are of diagnostic importance is:View Page

Red Cell Morphology
Acanthocytes

Acanthocytes have 3-12 thorn-like projections irregularly spaced around the cell. Since these cells have lost their discoid shape, they are frequently smaller than normal and have little or no central pallor. Acanthocytes have an excess of cholesterol and an increased surface area. Large numbers of these cells on a smear can be of diagnostic significance. The largest percentage, 50-100% of circulating red cells, can be seen in the rare abetalipoproteinemia (hereditary acanthocytosis). Acanthocytes are easily seen as horned cells in the smear shown on the right.

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